Lincoln Burrows is on death row for the murder of the vice presidents brother. He insists hes innocent and only his brother Michael Scofield believes him. As an engineer who helped design the prison where Lincoln is being held, Michael takes drastic measures to help his brother. He gets himself arrested and sent to the same prison so that with his knowledge of the building the two of them can escape together. However, while inside, Michael discovers a massive conspiracy that is determined to see Lincolns sentence carried out. Breaking out will be more difficult than he thought, but hes still going to try. Michael Scofield是一头陷于绝境欲拼死一搏的怒狮，他的兄弟Lincoln Burrows几个月就将被以谋杀罪处以死刑，但Michael坚信他是被冤枉的。为了拯救了自己的手足，Michael抢劫了一家银行，因此而被与Lincoln关进同一所监狱-- 福克斯河州立监狱。作为一名建筑工程师，他对监狱的建设蓝图了如指掌，带着Lincoln逃出生天也成为Michael入狱的唯一目的。 年长的犯人改造官Bellick教会了Michael很多监狱的生存之道。后来，在狱友Sucre的帮助下，Michael开始与其他帮派广泛结盟，包括前匪首John Abruzzi，和声名狼藉的劫机犯Charles Westmoreland。在监狱外，Michael只有一个盟友--他的辩护律师和老友Veronica Donovan，她也是Lincoln的...